1.  Fiscal crises in key economies — think China, Europe, and the U.S.
2.  Structurally high unemployment/underemployment — predicts social instability
3.  Water crisis — ask anybody in the western U.S.
4.  Severe income inequality — also predicts social instability
5.  Failure of climate change mitigation and adaption — no longer debating the earth’s flatness
6.  Greater incidence of extreme weather events — see #5
7.  Global governance issues — the need to overcome some national sovereignty issues.
8.  Food crisis — hard to imagine sitting here in America
9.  Failure of a major financial institution — my primary concern, leads straight to Wall Street
10. Profound political and social instability — symptom or cause?

This is the Top Ten from the “best & brightest.”   Now, what would YOU add to this list?